BRUKER TOXSCREENER™

Are you searching for a solution for targeted forensic screening? Are you looking for a way to confirm drugs in human body fluids? The Bruker ToxScreener is the answer to your questions and delivers reliable end results - every time. The challenges of forensic toxicology: Forensic laboratories are frequently required to perform comprehensive screening of complex samples to identify drugs and other toxicants. This is a very challenging task due to the enormous number of analytes covered, their wide range of concentration and the complexity of sample matrices tested. Within the field of forensic toxicology, there is high requirement for analytical certainty in the accuracy and completeness of the results, so as to ensure that they will stand up to scrutiny in a court of law. The benefits of QTOF technology for toxicological drug screening: In recent years, owing to the high level of specificity and sensitivity obtained from full scan exact mass data acquisition, the utilization of Quadrupole Time-of-Flight (QTOF) technology for forensic toxicology screening has increased. Furthermore, the ability to retrospectively interrogate data for unexpected compounds, or emergent new "designer" drugs has significantly increased the uptake and adoption of this technology. The application of QTOF technology for toxicological drug screening therefore offers forensic toxicologists a comprehensive solution for both targeted and nontargeted screening workflows. However, in order to realize this benefit, it is essential to have access to a high quality accurate mass reference database supported by powerful data processing software for cross referencing experimental observations. ToxScreener - The market leading solution for forensic screening and quantitation: The Bruker ToxScreener solution is designed specifically for use with Bruker QTOF mass spectrometers to enable comprehensive targeted forensic screening and confirmation of drugs and other toxicants in human body fluids, whilst delivering maximum confidence in the end result. The solution minimizes method development time for toxicological screening and is supplied with complete analysis protocols for the chromatographic and mass spectrometric analytical steps. The total analysis time including chromatographic separation and accurate mass detection is 20 minutes. At the heart of the ToxScreener is a high quality forensic database that includes accurate mass and retention time information for over 1800 compounds of forensic relevance. TECHNICAL DETAILS: ToxScreener: The all-in-one solution for forensic analysis. The ToxScreener is a complete solution for comprehensive forensic analysis. It relies on the powerful instrument platform of a compact or impact II QTOF and therefore is able to increase its specificity to new levels. Thanks to its usage of Apollo II ion source the ToxScreener is able to minimize false negative detections of low level drugs and their metabolites in complex biological matrices. Broadband CID (bbCID) Data Acquisition: During the entire chromatographic separation step, the QTOF mass spectrometer rapidly and continuously cycles between TOF-MS and bbCID MS/MS resulting in the seamless collection of a comprehensive catalogue of precursor and fragment ion data in a single analysis. The ability of QTOF instrumentation to collect 'all of the ions, all of the time' in both MS and MS/MS full scan modes results in a dataset that is complete and unrestricted. Once collected, the analyst can perform detailed targeted and / or non-targeted investigations if desired. The forensic toxicology database: To allow you to confidently identify drugs in human body fluids, the Bruker ToxScreener comes along with a high quality forensic toxicology database. This database has been carefully developed in co-operation with established forensic toxicology laboratories to provide you with accurate masses of fragment ions, adducts and isomer information as well as retention time data. APPLICATIONS: ToxScreener Workflow: Prior to analysis, depending on the analytical requirements, blood serum or urine samples are prepared using LLE, SPE or protein precipitation. They are then injected onto a reverse phase binary gradient UHPLC- QTOF system for mass selective detection and confirmation. The Bruker ToxScreener combines broadband CID (bbCID) QTOF data acquisition with the ToxScreener accurate mass forensic database and associated data mining software to bring the full power of exact mass screening to the forensic laboratory.