TOXTYPER™

Toxtyper™ delivers a robust and automated research-based drug testing solution based on the latest LC-MSn ion trap technology, the amaZon speed. The Toxtyper provides a combination of the highest performance LC-MS/MS and easy-to-use identification with the greatest transferability of results from lab to lab. The Toxtyper solution was developed to meet the needs of clinical research and forensic labs. The unique patented SmartFrag™ technology removes variation and the need for tuning from the MS/MS process. Data acquisition and post-processing is completely hidden by Compass OpenAccess, which provides a wizard for easy web-based access. • Unique and comprehensive library of over 830 compounds based on retention time, MS, MS2, and MS3 ion trap spectra • Full UHPLC-MSn screening method • Fast results within an 11 minute duty cycle • Ease-of-use by Compass OpenAccess sample management and fully automated reporting. TECHNICAL DETAILS: • Toxtyper: the solution for clinical research and forensic toxicology: The high demand in clinical research and forensic toxicology for comprehensive, specific, and transferable techniques has led to new developments in the field of Liquid Chromatography-tandem Mass Spectrometry (LC-MS). LC-MS, combined with library searching, is one of the most promising screening solutions for modern toxicology research. The Toxtyper solution uses state-of-the-art ultra high performance liquid chromatography (UHPLC) combined with true MSn and a comprehensive drug library. • Library of Drugs: The Toxtyper holds a high quality spectral library of more than 830 compounds of toxicology research interest with over 2,600 spectra of MS, MS2 and MS3 experiments. A novel library search module, as part of Brukers' proven Compass software package, allows for unambiguous and fast (11-minute duty cycle) drug identification. • Sample preparation for a wide range of analytes: Different well-established sample preparation methods, such as liquid-liquid extraction (LLE) and solid-phase extraction (SPE), can be used for the Toxtyper workflow and are well-suited for the extraction of a wide range of analytes such as hypnotics, neuroleptics, antidepres- sants, and many others. • Transferability by SmartFrag™: The Toxtyper solution is setting new standards in LC-MS/MS toxicology research and transferability from lab-to-lab. Bruker's patented SmartFrag technology virtually removes variation and tuning from the MS/MS process. Furthermore, results and libraries are easily transferable from lab-to-lab and from experiment-to-experiment. • Easy-to use: In current toxicology research workflows, LC-MS/MS software and instruments often require expert MS knowledge, which is not always available in research laboratories. The Toxtyper solution was developed with this in mind. The user is guided through the complete workflow with easy web-based access. Automated report generation and distribution enables fast inspection of research results. APPLICATIONS: • The Toxtyper Workflow: supports the complete workflow from sample submission to final research result reporting. "For research use only. Not for use in diagnostic procedures. Not available in every country. Please contact your local sales representative for more information." • Transferability of the Toxtyper from lab-to-lab: MS2 spectra of Amitryptilin measured on 7 different amaZon speed systems during an interlaboratory test. "For research use only. Not for use in diagnostic procedures. Not available in every country. Please contact your local sales representative for more information." • Compass OpenAccess: is guiding users through the complete workflow. "For research use only. Not for use in diagnostic procedures. Not available in every country. Please contact your local sales representative for more information." • amaZon speed: The Toxtyper platform is built on the amaZon speed, the latest innovation in ion trap MSn technology. "For research use only. Not for use in diagnostic procedures. Not available in every country. Please contact your local sales representative for more information."