MICROTOF FOCUS II

microTOF focus II: The High Performance Molecular Formula Solution. Molecular Formula Verification, De novo Formula Generation, Multi-Target Screening, Biomarker Discovery and Intact Protein Analysis are just a few application examples which can be covered by high performance TOF-MS systems. The micrOTOF II represents the gold standard in terms of performance and flexibility utilizing this technology. Outstanding resolution and mass accuracy in combination with true isotopic pattern allows unambiguous sum formula determination or high resolved extracted ion chromatograms with <2mDa mass window in combination with any HPLC, UHPLC, CE and even GC. TECHNICAL DETAILS: A resolution of >16.500 FWHM (typically 18.000 FWHM) and a mass accuracy of <2ppm makes the micrOTOF II the reference instrument in its class. This performance was achieved by development of new ion optics in combination with improved calibration routines. A wide variety of ion sources makes the micrOTOF the most flexible instrument in the market. ESI, ESI-nano, APCI, APPI are just a few examples for possible ionisation techniques. The newly developed GC/APCI source enables the coupling of a LC or a GC on the same instrument. Even laser ionisation with outstanding selectivity and sensitivity is possible. • TIP™ – True Isotopic Pattern with SmartFormula algorithm: Replacing the former approach of just using the measured mass for formula determination, the micrOTOF II adds a second dimension into the routine: Analysis of the isotope profile provides the so-called “True Isotopic Pattern” (TIP) which is matched against the measured spectrum – leading to results with significantly increased confidence. • Powerful software environment: The Compass software environment handles all aspects of system control and data handling with an intuitive and easy-to-use graphical user interface (GUI). The LC/MS workflow can be fully automated with a simple method approach. Compass integrates the micrOTOF II with all popular HPLC and nanoLC systems to match your separation needs. The micrOTOF II system can be adapted to an “Open Access Environment” covering typical aspects of multiple users with various samples. APPLICATIONS: • Pesticide Screening: Multiple-Compound Pesticide Screening: Accurate and reliable screening for the presence of pesticides in food is a major analytical task. The increasing number of pesticides poses special analytical challenges, with hundreds of different pesticide targets assessed during the screening of each sample. • Forensic Screening: The screening for drugs of abuse in human, equine and canine urine, saliva and other body fluids is a key application in many governmental and non-governmental laboratories. Rapid, unambiguous detection and identification of drugs and related compounds in numerous samples are essential prerequisites for forensic drug screening. Since positive samples returns can have severe consequences for the tested person / animal, it is of utmost importance to acquire reliable data.